A brief talk on the cancer antigen 19 9
Cancer antigens generally refer to antigenic substances that are newly or overexpressed during tumorigenesis and development. The possible mechanisms by which the body produces cancer antigens are: 1 gene mutation; 2 cells that are not expressed in the cell carcinogenesis are activated; 3 abnormalities occur in a certain writing process of the antigen synthesis process (such as abnormal glycosylation results in the production of specific carrier protein degradation products) Abnormal, ectopic expression of 4 embryonic antigens or differentiation antigens; 5 overexpression of certain gene products, especially signal transduction molecules; 6 expression of exogenous genes (such as viral genes). Tumor-targeted clinical treatment for tumor-specific cancer antigens is a therapeutic approach with broad application prospects. Obtaining immune cells capable of highly recognizing cancer antigens, using genetic engineering methods and TCR-T and CAR-T are the most commonly used methods for